On the most basic set mining level, you need to need to be getting 10 to 1 on your money when you hit a set. So the Villains have to have, remaining in their chip stack added to what is in the pot, way more than 10x whatever you have to put in to call this 3 bet.
The reason that you have to be getting way more than 10x when you stack off is to balance the times that you only get 3x return when they fold to your first bet.
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